This microfilm contains letters and drafts of replies, memoranda, lists of plants and shrubs, observations on natural history, diary notes, extracts from reading, and recipes. There is a "Catalogue of Books given to [Friends] Publick School of Philadelphia" by Collinson dated 1749. There is a copy by Collinson of a May 16, 1560 note by Elizabeth I of a gift of old clothes to her maids of honor. A 1811 letter is from C. S. Collinson to Aylmer Bourke Lambert.

The collection includes letters between Hutchinson and his uncle Israel Pemberton, written while Hutchinson was a student of medicine in London. There are also 12 tickets of admission to medical lectures in Philadelphia and London, including one given by William Hunter, and 3 unused cards of admission to Hutchinson's own lectures. Miscellaneous items include Hutchinson's marriage certificate; genealogical data on the Hutchinson, Hare, and Pemberton families; and stock certificates, 1857-1872, of the McKean and Elk Land and Improvement Company. Materials dated post-1793 are to and from Hutchinson family members.